Scientists found that drinking orange juice daily alters thousands of genes in immune cells.
Many of these genes control blood pressure, reduce inflammation, and regulate sugar metabolism.
These mechanisms play a key role in supporting long-term cardiovascular health.
David C. Gaze from the University of Westminster explains that orange juice triggers measurable changes in regulatory genes.
Studies Show Reduced Inflammation and Blood Pressure
Researchers asked adults to drink 500 ml of pasteurised orange juice daily for two months.
After 60 days, stress-related genes such as NAMPT, IL6, IL1B, and NLRP3 became less active.
The SGK1 gene, which affects kidney sodium retention, also showed reduced activity.
Scientists say these changes relax blood vessels, lower inflammation, and protect heart health.
Hesperidin, a flavonoid in oranges, contributes antioxidant and anti-inflammatory effects while supporting cholesterol and sugar balance.
Body type influences response: overweight individuals show greater changes in fat-metabolism genes, while lean participants show stronger inflammation-gene shifts.
Orange Juice Supports Heart and Metabolic Health
Analyses of 15 controlled studies with 639 participants show orange juice reduces insulin resistance and LDL cholesterol.
Overweight participants experienced slightly lower systolic blood pressure and higher HDL after several weeks of daily intake.
Metabolite studies reveal orange juice improves energy use, cell communication, and inflammatory pathways.
Blood orange juice increased gut bacteria producing short-chain fatty acids, linked to healthier blood pressure and lower inflammation.
In metabolic syndrome patients, orange juice improved endothelial function, enhancing vessel relaxation and lowering heart-attack risk.
Research from a Brazilian orange juice plant found workers had lower apo-B levels, reducing dangerous cholesterol particles.
Overall, evidence shows orange juice lowers inflammation, improves circulation, and strengthens markers of heart health.
