Researchers tested VER-01, an experimental cannabis extract, on adults suffering persistent lower back pain. Patients reported meaningful reductions in pain over several months. Unlike smoking cannabis, the extract delivers precise doses, minimizing psychoactive effects and avoiding respiratory risks. Scientists designed VER-01 to reduce pain while limiting addiction or serious side effects. Chronic lower back pain affects over 619 million people worldwide and remains the leading cause of disability. Current treatments, such as opioids, carry high addiction potential, while NSAIDs risk heart and gastrointestinal problems. Many patients struggle to find effective, safe solutions.
Clinical Trial Demonstrates Measurable Relief
The study enrolled 820 adults who failed to respond to non-opioid medications. Researchers divided participants into two groups: one received VER-01, and the other received a placebo. Participants recorded pain on a 0–10 scale. After three months, VER-01 users reported a 1.9-point reduction, while placebo participants reported only 0.6 points. Researchers extended the trial to six months, during which VER-01 patients experienced an additional 1.1-point decline. Patients also reported improved sleep quality and physical function. Scientists published the results in Nature Medicine. Neuroscience lecturer Jan Vollert noted the relief could significantly improve patients’ daily lives. He cautioned, however, that further trials are necessary to confirm the findings.
Safety, Side Effects, and Key Differences from Cannabis
Patients mainly experienced mild dizziness, nausea, and drowsiness. Researchers observed no signs of abuse, dependency, or long-term safety concerns. Each VER-01 dose contains 2.5 milligrams of THC, the main psychoactive component in cannabis, along with other compounds. Experts warn that smoking cannabis differs greatly from taking VER-01. Vollert compared the two to eating hazelnuts versus eating Nutella: related origins but entirely different experiences. Researchers plan additional trials comparing VER-01 with opioid treatments. If future studies confirm efficacy, the extract could provide a safer, effective alternative for millions living with chronic lower back pain worldwide.
